19 01 Base Architecture Ovarian Carcinoma HGSC BRCA-wild-type
Abstract
High-Grade Serous Ovarian Carcinoma (HGSC) represents the most lethal gynecological malignancy, with 5year survival rates below 30% for advanced stages. A subset of HGSC tumors exhibit estrogen receptor (ER)expression with luminal characteristics (HGSC-ER-like), creating a unique metabolic and spatial architecturedistinct from basal-type HGSC. Understanding the mechanistic basis of this tumor’s extreme adaptabilityrequires integration of multiple biological scales: from tissue-level equilibrium to subcellular organellar dynamics.
Fields of Study & Subjects
PARP inhibition in cancer therapy
Ovarian cancer diagnosis and treatment
Cancer Mechanisms and Therapy
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 7 January 2026
- Language
- EN