19 02 Metastasis Base Architecture Ovarian Carcinoma HGSC BRCA-wild-type
Abstract
High-Grade Serous Ovarian Carcinoma (HGSC) exhibits a unique metastatic pattern fundamentally differentfrom other solid tumors: rather than hematogenous dissemination to distant organs, HGSC primarily spreadsthrough transcoelomic seeding within the peritoneal cavity, with secondary colonization of lung, liver, andlymph nodes. The ER-like subset of HGSC displays distinct metabolic characteristics, including lipid/glutaminedependence and estrogen receptor expression, creating specialized adaptation requirements for each metastaticniche.
Fields of Study & Subjects
Ovarian cancer diagnosis and treatment
PARP inhibition in cancer therapy
Cancer Research and Treatments
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 7 January 2026
- Language
- EN