Integrative Functional Genomics and Fine-Mapping Identify Regulatory Mechanisms of Multivariate Obesity GWAS and Its Cardiometabolic Implications
Abstract
Here we construct an integrative multivariate obesity GWAS framework (mvObesity) by jointly modeling five obesity-related traits and systematically integrating functional genomic and single-cell datasets. We delineate shared and trait-specific regulatory architectures, identify high-confidence effector genes, and reveal coordinated neuro-metabolic genetic regulation and cell-type-specific mechanisms underlying cardiometabolic risk.
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 7 January 2026
- Language
- EN
- Document type
- Dataset