20 02 Metastasis Base Architecture Acute Myeloid Leukemia AML

Extramedullary involvement in acute myeloid leukemia represents a critical clinical challenge, occurring in 3050% of patients and correlating with adverse prognosis . While bone marrow remains the primary diseasesite, leukemic cells colonize diverse tissue environments—each presenting unique biochemical landscapes, oxygentensions, and immune contexts. Understanding how malignant cells adapt to these heterogeneous niches isessential for rational therapeutic design.