Derivation of the Hodgkin–Huxley Model

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Authors: Nicholas Bader
Cited by: 0

Abstract

We derive the Hodgkin–Huxley model from a membrane–circuit analogy and extend it to the one-dimensional cable equation. The membrane is treated as a parallel plate capacitor with conductances for Na+, K+, and leak. The Na+ and K+ pathways use m, h, n voltage-dependent gating. The leak term is ungated with a fixed reversal potential. The aim is a concise, consistent derivation that explicitly links the biophysics to the equations. While many graduate-level texts discuss elements of this derivation, in my experience it is difficult to find a contemporary derivation that is both complete—including the cable extension—and conceptually accessible to undergraduate readers.

Fields of Study & Subjects

Nanopore and Nanochannel Transport Studies ATP Synthase and ATPases Research Lipid Membrane Structure and Behavior

Publication details

Journal / source
Zenodo (CERN European Organization for Nuclear Research)
Publication date
7 January 2026
Language
EN