Phase IV Singularity Crossing: A Deterministic Framework for Cellular Rejuvenation via Stability-Entropy Phase Space Navigation
Abstract
This paper presents a theoretical and experimental framework for deterministic cellular rejuvenation using the CL5D (Cellular-Level 5-Dimensional) model. It identifies a mathematical "Phase IV" singularity that allows cells to transition from a senescent state (Phase III) back to a youthful state (Phase I). The research details the engineering of a resonant piezoelectric-capacitive hybrid system used to deliver a specific Intervention Force (Iv=425~mV) to achieve a complete transcriptomic information reset in human fibroblasts.
Fields of Study & Subjects
Planarian Biology and Electrostimulation
Microfluidic and Bio-sensing Technologies
3D Printing in Biomedical Research
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 7 January 2026
- Language
- EN
- Document type
- Preprint