Comprehensive Review on Analytical Methods of Atorvastatin

Atorvastatin is potent statin in the management of hyperlipidaemia. It helps in prevention of cardiovascular diseases and extensively analysed using a wide range of advanced analytical techniques. Atorvastatin is a bad cholesterol lowering lipoprotein and recognised as pioneer to show efficacy in reducing triglycerides level in individuals with elevated triglyceride levels in the blood. This review presents a systematic and thorough examination of the current methodologies employed for the quantitative and qualitative determination of atorvastatin in pharmaceutical formulations and biological matrices. Various instrumental techniques are utilized to detect and quantify atorvastatin, including but not limited to HPLC, mass spectroscopy-assisted chromatography, spectroscopic approaches in ultraviolet and visible ranges, capillary electrophoresis, advanced thin layer and ultra performance chromatography as well as Raman and infrared spectroscopy. Each technique is evaluated based on its sensitivity, specificity, robustness, and suitability for pharmaceutical quality control, pharmacokinetic studies, and stability testing. The review highlights recent advances in instrumental analysis and provides a critical comparison of these techniques, guiding researchers and analysts in the selection of appropriate methods for atorvastatin assessment in diverse contexts. The consolidation of these approaches reflects the evolving landscape of pharmaceutical analysis for this vital drug.