Menopause and Bone Health: Hormonal Mechanisms, Osteoporosis Risk, and Management Strategies

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Authors: Dimmiti Jayasri*, Kethireddy Pradeep, Bitra Indrani, T. Purna Santhosh Kumar
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Abstract

A decrease in estrogen levels after menopause, a normal biological transition, has a substantial effect on bone metabolism and raises the risk of osteoporosis. Reduced estrogen speeds up bone resorption, which lowers bone mineral density and increases the risk of fracture, especially in postmenopausal women. With a focus on the mechanisms driving postmenopausal osteoporosis, this article examines the physiological link between menopause and bone health. It also covers evidence-based preventive measures, such as consuming enough calcium and vitamin D, engaging in weight-bearing activity, and making lifestyle changes like quitting smoking and drinking less alcohol. Additionally, pharmaceutical treatments including selective estrogen receptor modulators, bisphosphonates, and hormone replacement therapy—are examined for their potential to prevent and treat osteoporosis. To preserve skeletal strength and lower the risk of fracture, early screening and prompt intervention are essential. In general, the development of successful preventative and therapeutic strategies to enhance the quality of life for postmenopausal women is made possible by an awareness of the multifaceted impact of menopause on bone health.

Fields of Study & Subjects

Bone health and osteoporosis research Menopause: Health Impacts and Treatments Bone Metabolism and Diseases

Publication details

Journal / source
Zenodo (CERN European Organization for Nuclear Research)
Publication date
7 January 2026