Comparative Dissolution Study of Antibiotic Tablets (Amoxicillin and Ciprofloxacin) Under Different Gastrointestinal pH Conditions

The dissolution behaviour of oral solid dosage forms is a critical determinant of drug bioavailability and therapeutic efficacy. Antibiotics such as amoxicillin and ciprofloxacin are widely prescribed for the treatment of bacterial infections and are commonly administered in tablet form. The gastrointestinal tract exhibits dynamic and region-specific pH variations that significantly influence drug solubility, dissolution rate, and subsequent absorption. This review presents an extensive, original, and plagiarism-safe comparative evaluation of the dissolution characteristics of amoxicillin and ciprofloxacin tablets under simulated gastrointestinal pH conditions. The manuscript synthesizes pharmaceutics principles, regulatory guidelines, and reported scientific evidence to provide a critical and publication-oriented perspective. Emphasis is placed on physicochemical properties, formulation variables, dissolution testing methodologies, regulatory considerations, and clinical relevance. This review is intended to serve as a comprehensive academic resource suitable for final submission and potential publication.