Perindopril Sublingual Tablets: Formulation and Evaluation

The objective of the present study was to develop and optimize a sublingual tablet of Perindopril which is effective in the treatment of hypertension. Perindopril tablets were prepared by direct compression method using different ingredients Sodium starch glycolate, Spray dried lactose, Starch, Talc and Magnesium stearate. The compressed tablets were evaluated for physical properties including hardness, weight variation, thickness, friability, drug content, wetting time, water absorption ratio, in-vitro disintegration time, in-vitro dissolution study and drug release kinetic study. All the physical properties evaluated for the compressed tablets have shown the results within the acceptable range of Pharmacopoeia limits. F10 was considered as the optimized formulation, which provided short wetting time of 64 sec, water absorption ratio of 66 and In-vitro disintegration time of 65 sec. From the above results, it indicated that the amount of super disintegrant i.e. Sodium starch glycolate was significantly affected the dependent variables like wetting time, water absorption ratio and in-vitro disintegration time. F10 has shown the best in-vitro drug release profile i.e., 97.83% during the end of 10 min. The in-vitro drug release data of all Perindopril sublingual tablets were subjected to testing by linear regression analysis according to Zero order equation, first order equation, Higuchi’s equation and Korsmeyer-Peppas equation to comprehend the mechanism of drug release. According to the results the drug release followed First order release kinetics with Non-Fickian diffusion mechanism.