Dynamic Medicine — Part V Toward Dynamic Therapeutics: Designing Treatment for Adaptive Biological Systems

This paper is Part V of the Dynamic Medicine series and develops the concept of dynamic therapeutics — an approach to treatment design that accounts for system behavior, resilience, and temporal phase rather than assuming stable and uniform drug effects. Building on the Universal Resonance Model (URM), the paper argues that therapeutic efficacy depends on alignment between intervention and system state, and that many treatment failures arise from phase mismatch rather than insufficient biological activity. The paper reframes therapy as a regulatory interaction with an adaptive biological system, emphasizing timing, stability restoration, and system responsiveness over static target inhibition. By focusing on therapeutic windows, adaptive capacity, and system-level stabilization, it provides a conceptual foundation for designing treatments that produce durable effects without excessive intervention. This work extends the system-dynamic analysis of disease and treatment introduced in Parts I–IV and serves as a bridge toward future clinical application and dynamic treatment strategies.