Short-Scale Trials, Long-Scale Systems: Why Mouse Models Cannot Certify Genome-Level Interface Interventions (CMEM–IFST Diagnostic Note)

CMEM Framework Collection Link This diagnostic note examines why short-horizon animal trials cannot certify the safety or stability of genome-level interventions when the affected system boundary is generational. Rather than proposing mechanisms, predictions, or policy recommendations, the document applies the CMEM–IFST framework to identify a structural mismatch between evidence windows and system boundaries. Genome-scale interventions alter interface-defining layers that propagate through inheritance loops, making the relevant system not the individual organism but the lineage runtime across extended temporal scales (Δt). Under this interpretation, short-scale trials (mouse → pig → primate → human) can only confirm acute survival or non-failure snapshots. They are structurally incapable of certifying long-term interface coherence, reversibility, or stability across generations. The note further identifies loss of individual variance as a critical indicator of high freeze-order risk (F3–F4), observable across agricultural systems, artificial breeding, digital and mechanical bionics, and technological human civilization itself. This document records a boundary condition only: lineage-scale claims require lineage-scale evidence windows. It makes no claims regarding outcomes, probabilities, mechanisms, or inevitability.