SYNTHESIS OF INDOLES WITH THIAZOLIDINONE DERIVATIVES AND BIOLOGICAL ACTIVITY

Ethyl 2-methyl-1H-indole-3-carboxylate (1) was obtained by reaction with phenylhydrazine and ethyl-3-oxobutanoate. Compound 1 reacted with hydrated hydrazine and furnished compound 2. Compound 3-5 were synthesized by reaction of substituted aromatic aldehydes with compound 2 and then compounds 3-5 were converted in to compounds 6-8 by interaction with triethylamine in presence of dioxane. All the synthesized compounds were characterized by their spectral and elemental analysis data. Antifungal activity of the synthesized compounds have been evaluated and compared with standard drug fluconazole.