A New Beginning in Thinking About Disease Disease as a Consequence of a State Change in the Cellular Environment

This conceptual essay proposes a shift in medical thinking by suggesting that many diseases do not originate from primary molecular defects or dysfunctional biochemical pathways. Instead, disease often begins with a change in the physical state of the cellular environment, particularly the cell membrane. Such state transitions are collective, non‑linear phenomena governed by physical thresholds rather than stepwise biochemical mechanisms. Biochemical alterations commonly observed in disease may therefore represent secondary consequences of an underlying physical state change. Viewing disease as a stabilized pathological state provides a unifying framework that connects prebiotic principles of life emergence with modern pathophysiology and opens new perspectives for prevention and therapy.