THE SIGNIFICANCE OF DRIVER GENE MUTATIONS JAK2, CALR, AND MPL IN CHRONIC MYELOPROLIFERATIVE DISEASES
Abstract
Resume. Driver mutations in the JAK2, CALR, and MPL genes play a crucial role in the diagnosis of myeloproliferative disorders, enabling accurate identification of their type and exclusion of other diseases with similar symptoms. Purpose. To determine the role of driver gene mutations (JAK2, CALR, and MPL) in chronic myeloproliferative neoplasms (MPNs), including their significance in pathogenesis, diagnosis, and clinical management. Keywords: Myeloproliferative diseases, diagnosis, driver genes: JAK2, CALR, MPL
Fields of Study & Subjects
Myeloproliferative Neoplasms: Diagnosis and Treatment
Acute Myeloid Leukemia Research
Platelet Disorders and Treatments
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 11 January 2026