Dementia as a Systems Transition: A Universal Resonance Model (URM) Perspective

Dementia research has achieved major advances in biomarkers and disease characterization, yet clinical impact remains limited. This paper presents a conceptual interpretation of dementia using the Universal Resonance Model (URM), viewing neurodegeneration as a long-term systems transition rather than a discrete disease event. Dementia is described as a process of declining resilience, maladaptive resonance between interacting physiological subsystems (neural, vascular, immune, metabolic, autonomic), and eventual consolidation into a degenerative attractor. Biomarkers are reframed as instability signals rather than disease-defining entities, and therapeutic effects are understood as phase-dependent and critically timing-sensitive. This paper is a conceptual position document, intended to provide a dated and stable formulation of this perspective rather than a claim of final explanation. Conceptual framework only; no new experimental, clinical, or epidemiological data are included.