Scleroderma as a Systems Transition — A Universal Resonance Model (URM) Perspective

Systemic sclerosis (scleroderma) is traditionally described through immune dysregulation, vasculopathy, and fibrosis, yet its clinical course is highly variable and difficult to predict. This paper presents a conceptual interpretation of scleroderma as a long-term systems transition from a Universal Resonance Model (URM) perspective. The disease is described as a process of declining resilience, maladaptive resonance between interacting physiological subsystems, and eventual consolidation into structurally locked states. Clinical phases are interpreted as dynamic regimes rather than fixed categories, and treatment effects are understood as phase-dependent and critically timing-sensitive. Conceptual framework only; no new experimental, clinical, or epidemiological data are included.