Inflammatory Bowel Disease as a Systems Transition — A Universal Resonance Model (URM) Perspective

Inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, is characterized by chronic intestinal inflammation, fluctuating activity, and highly variable response to therapy. This paper presents a conceptual interpretation of IBD as a long-term systems transition from a Universal Resonance Model (URM) perspective. Disease dynamics are described in terms of declining resilience, maladaptive resonance between immune, microbiome, and epithelial barrier loops, phase shifts between inflammatory and compensatory regimes, and eventual structural and functional lock-in. Biomarkers and clinical measures are interpreted as phase markers and instability signals rather than static disease labels, and therapeutic effects are viewed as inherently phase-dependent and critically timing-sensitive. Conceptual framework only; no new experimental, clinical, or epidemiological data are included.