Evaluation of Combined Curcumin and Cassia fistula Therapy in the Management of Hepatotoxicity and Non-Alcoholic Fatty Liver Disease

Hepatotoxicity is a major cause of liver dysfunction resulting from exposure to drugs, chemicals, and xenobiotics, often leading to oxidative stress and inflammatory damage. Curcumin from Curcuma longa possesses strong antioxidant and anti-inflammatory properties that protect hepatocytes by reducing lipid peroxidation and modulating key signaling pathways. Cassia fistula, rich in flavonoids and phenolic compounds, enhances hepatic antioxidant defenses and stabilizes liver cell membranes. The combined use of curcumin and Cassia fistula provides synergistic hepatoprotection by reducing oxidative stress, suppressing inflammation, improving liver enzyme levels (ALT, AST, ALP), and preserving hepatic architecture. This combination represents a promising natural approach for the prevention and management of hepatotoxicity.