Inflammatory Myopathies as a Systems Transition — A Universal Resonance Model (URM) Perspective

Inflammatory myopathies are rare but biologically complex autoimmune muscle diseases characterized by immune-mediated muscle injury, weakness, fatigue, and variable systemic involvement. This paper presents a conceptual interpretation of inflammatory myopathies as long-term systems transitions from a Universal Resonance Model (URM) perspective. Disease dynamics are described in terms of declining resilience, maladaptive resonance between immune, muscle, and metabolic loops, phase shifts between inflammatory and degenerative regimes, and eventual consolidation into structurally and functionally constrained states. Biomarkers and functional measures are interpreted as phase markers and instability signals rather than static disease labels, and therapeutic effects are viewed as inherently phase-dependent and timing-sensitive. Conceptual framework only; no new experimental, clinical, or epidemiological data are included.