TCR-T cells targeting tissue-resident memory CD8+ T cell-derived neoantigens sensitize pMMR colorectal cancer to immunotherapy
Abstract
This project investigates mechanisms of immunotherapy resistance in pMMR colorectal cancer. We performed 10x Genomics scRNA-seq and scTCR-seq on CD8⁺ T cells from matched tumor tissue and peripheral blood, together with tumor whole-exome sequencing (WES) to support neoantigen discovery and validation.
Fields of Study & Subjects
Cancer Immunotherapy and Biomarkers
Immunotherapy and Immune Responses
CAR-T cell therapy research
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 1 January 2026
- Document type
- Dataset