What are the key pathophysiological changes in the coagulation system observed in patients with acute-on-chronic liver failure?
Abstract
ACLF induces complex changes in coagulation characterized by both pro- and anticoagulant factor impairments, resulting in a rebalanced hemostatic state that may lead to either bleeding or thrombotic events, demanding careful clinical evaluation.
Fields of Study & Subjects
Liver Disease and Transplantation
Blood Coagulation and Thrombosis Mechanisms
Trauma
Hemostasis
Coagulopathy
Resuscitation
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 12 January 2026