glenritschel/ebv-immune-scarring: EBV immune scarring — analysis code (v1.0.0)
Abstract
Analysis code for "Single-Cell Signatures of EBV-Associated Immune Scarring in Systemic Sclerosis B Cells" Version: 1.1.0 (SSc-specific analysis) Dataset: GSE195452 (Systemic sclerosis patient PBMCs) Submission: Biology (MDPI), February 2026 Key analyses: scVI-based B cell clustering from SSc patient PBMCs Immune scarring signature scoring (ISG, HLA, NF-κB) Pseudobulk differential expression (PyDESeq2) LINCS L1000 drug reversal screening BTK inhibitor identification and validation All code is fully reproducible with provided documentation.
Fields of Study & Subjects
Systemic Sclerosis and Related Diseases
Single-cell and spatial transcriptomics
T-cell and B-cell Immunology
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 13 January 2026