Reversing Alzheimer's & Dementia: Using Systems Pharmacology & A Multi-Target Approach

Zenodo (CERN European Organization for Nuclear Research) 2026 Preprint Open access

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Authors: Mohamad Al-Zawahreh, Michał Wójtków
DOI: 10.5281/zenodo.18229833
Cited by: 0

Abstract

Alzheimer's Disease remains therapeutically intractable due to network compensation mechanisms that render monotherapy ineffective. This systems pharmacology study validates a multi-target six-node intervention strategy achieving 31-40x superiority over current standard-of-care through convergent computational validation across Framework 50 (AI-driven network pharmacology) and IMMUNO-SERENE (deterministic neuroimmune modeling), with

Fields of Study & Subjects

Alzheimer's disease research and treatments Computational Drug Discovery Methods Cholinesterase and Neurodegenerative Diseases

Publication details

Journal / source
Zenodo (CERN European Organization for Nuclear Research)
Publication date
13 January 2026
Language
EN
Document type
Preprint