RNA-Sequencing data: Differentially regulated genes in unstimulated (CTL) and with noradrenaline stimulated (NA) isolated murine neutrophils with a specific deletion of the Adrb2 (KO) vs. controls (WT)

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Authors: Sandra Dieterich
Cited by: 0

Abstract

3 Cre- and 3 Cre+ mice with a neutrophil specific deletion of the adrenoreceptor beta 2 were sacrificed and neutrophils were isolated from the long bones. Afterwards, an in vitro experiment was conducted where half of the neutrophils of each mouse were stimulated for 3 hours at 37 °C with 10^-5 M Noradrenaline while the other half was kept in normal culture medium as control. Neutrophil RNA was isolated and RNA-sequencing performed. The following comparisons were analyzed: KO_CTLvsWTCTL_deg_all = Unstimulated Cre+ neutrophils vs. Unstimulated Cre- neutrophils KO_NAvsWT_NA_deg_all = Stimulated Cre+ neutrophils vs. Stimulated Cre- neutrophils

Fields of Study & Subjects

Receptor Mechanisms and Signaling Neutrophil Myeloperoxidase and Oxidative Mechanisms Inflammation biomarkers and pathways

Publication details

Journal / source
Zenodo (CERN European Organization for Nuclear Research)
Publication date
13 January 2026
Document type
Dataset