OSHQOZON RAKIDA IMMUNOTERAPIYA REZISTENTLIGINING O'SMA MIKROMUHITIGA BOG'LIQ MEXANIZMLARI

Zenodo (CERN European Organization for Nuclear Research) 2026 Open access

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Authors: Tojiddinov Otaxon Аbdullayevich, Madaliev Аxror Аliyevich, Kuryozova Gulasal Komuljonovna
DOI: 10.5281/zenodo.18231154
Cited by: 0

Abstract

Mazkur maqolada oshqozon rakida immunoterapiya samaradorligining nega bemorlar o‘rtasida keskin farq qilishi masalasi o‘sma mikromuhiti nuqtayi nazaridan tahlil qilinadi. Tahlil shuni ko‘rsatadiki, immunosupressiv makrofaglar va regulyator T-hujayralarning ko‘payishi, stromal to‘qimaning zichlashuvi, gipoksiya va metabolik moslashuv immun javobni bosib, chekpoint ingibitorlarining ta’sirini cheklaydi. Rezistentlik alohida molekulyar buzilish emas, balki butun o‘sma tizimining immun bosimga moslashuvi sifatida shakllanadi. Ushbu yondashuv davolashni faqat o‘smani emas, balki uning mikromuhitini ham nishonga olish zarurligini ko‘rsatadi.

Fields of Study & Subjects

Cancer Immunotherapy and Biomarkers Immune cells in cancer T-cell and B-cell Immunology

Publication details

Journal / source
Zenodo (CERN European Organization for Nuclear Research)
Publication date
13 January 2026