Alzheimer's Disease, Parkinson's Disease, and Coma as Distinct Modes of Breakdown in Neural Integration and Brain Communication

This preprint presents a systems-level conceptual framework linking Alzheimer’s disease, Parkinson’s disease, and coma as distinct modes of breakdown in neural integration and brain communication. The model proposes that these conditions share a common architectural failure of large-scale brain integration, differing primarily in timescale, depth, and reversibility. Alzheimer’s disease is interpreted as a slow structural disintegration of neural networks, Parkinson’s disease as a progressive disruption of oscillatory and functional coordination, and coma as a rapid global collapse of integrative mechanisms driven by metabolic and perfusion failure. The work emphasizes functional organization, network dynamics, and system-level behavior rather than molecular or biomarker-based explanations. It is intended as a hypothesis-driven theoretical contribution aimed at stimulating further research into shared mechanisms of chronic neurodegeneration and acute loss of consciousness