How is the AUC impacted by strong CYP2D6 inhibitors and doxorubicin?

Zenodo (CERN European Organization for Nuclear Research) 2026 Open access

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Authors: Tripdatabase
DOI: 10.5281/zenodo.18237210
Cited by: 0

Abstract

The interaction between strong CYP2D6 inhibitors and doxorubicin can increase the drug's AUC, suggesting higher systemic exposure and potential for increased adverse effects.

Fields of Study & Subjects

Pharmacogenetics and Drug Metabolism Drug Transport and Resistance Mechanisms Chemotherapy-induced cardiotoxicity and mitigation

Publication details

Journal / source
Zenodo (CERN European Organization for Nuclear Research)
Publication date
13 January 2026