Identification of kinases and phosphatases activated by Tau expression.
Abstract
We combined loss-of-function genetic approaches with a transcriptome wide network reconstruction method to identify kinase and phosphatase targets controlled by expression of Tau, encoded by MAPT. Candidate kinases which include enzymes that support Tau polymerization and those that function in cellular processes affected by Tau synthesis included PRKCZ, CAMKV, CALM3, PRKAR2B and the cyclin dependent kinase CDK5.
Fields of Study & Subjects
Alzheimer's disease research and treatments
Protein Kinase Regulation and GTPase Signaling
Bioinformatics and Genomic Networks
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 14 January 2026
- Document type
- Preprint