Cubosomes: A Potential Carrier for Drug Delivery

Cubosomes are nanostructured liquid crystalline particles that are self-assemble from amphiphilic lipids in the presence of stabilizers. These nanoparticles have attracted considerable interest due to their distinctive structural, physicochemical, and biological properties. Their large internal surface area, biocompatibility, and ability to encapsulate both hydrophilic and lipophilic drugs make them ideal candidates for controlled and targeted drug delivery. Compared with conventional systems, cubosomes offer superior drug-loading capacity, sustained release, and site-specific delivery through oral, topical, ocular, and parenteral routes. This article reviews their structure, preparation methods, characterization, applications, and future prospects as next generation nanocarriers.