IM-JW/ticagrelor-popPK: v1.0.0 - Initial release

Ticagrelor Population Pharmacokinetic Analysis Code repository for the manuscript: "Population pharmacokinetics of ticagrelor in patients with acute coronary syndrome: A pooled pharmacokinetic analysis" Overview This repository contains R and mrgsolve code for virtual cohort generation, population PK simulation of ticagrelor and AR-C124910XX, and dose optimization analysis. File Description Virtual Cohort Generation (R scripts) 2016 csv generation.R - Generate virtual patients from Li et al. 2016 (Study 1) 2017_60 csv generation.R - Generate virtual patients from Röshammar et al. 2017 (60mg) 2017_90 csv generation.R - Generate virtual patients from Röshammar et al. 2017 (90mg) mrgsolve Model Files (.cpp) 2016_mod_0_cov add.cpp - ADME structure for Study 1 2017_60_mod_0.cpp - ADME structure for Study 2 (60mg) 2017_90_mod_0.cpp - ADME structure for Study 2 (90mg) Simulation [1] sim_csv_file.R - Simulation execution script [2] sim_control_making.R - Generate simulation control parameters Data final_data_set_base.csv - Pooled virtual patient dataset (n=1,000) Requirements R (≥ 4.3.1) mrgsolve tidyverse References Li J, et al. Population pharmacokinetics of ticagrelor in patients with acute coronary syndromes. Int J Clin Pharmacol Ther. 2016;54:666-674. Röshammar D, et al. Population pharmacokinetics of ticagrelor and AR-C124910XX in patients with prior myocardial infarction. Int J Clin Pharmacol Ther. 2017;55:416-424. License MIT License