Chronology of the reviewed publications on brucellosis using the pregnant mouse model

References clustered within a box indicate studies performed by the same research group or related researchers [37,38,39,40,41,61,62,63,64,65,66,67,68,69,71,72,73,74,75,76,82,83]. (Created with Biorender.com). References 37. Tobias, L.; Schurig, G.G.; Cordes, D.O. Comparative Behaviour of Brucella abortus Strains 19 and RB51 in the Pregnant Mouse. Res. Vet. Sci. 1992, 53, 179–183. https://doi.org/10.1016/0034-5288(92)90107-D. 38. Tobias, L.; Cordes, D.O.; Schurig, G.G. Placental Pathology of the Pregnant Mouse Inoculated with Brucella abortus Strain 2308. Vet. Pathol. 1993, 30, 119–129. https://doi.org/10.1177/030098589303000204. 39. Kim, S.; Dong, S.L.; Watanabe, K.; Furuoka, H.; Suzuki, H.; Watarai, M. Interferon-γ Promotes Abortion Due to Brucella Infection in Pregnant Mice. BMC Microbiol. 2005, 5, 22. https://doi.org/10.1186/1471-2180-5-22. 40. Wang, Z.; Wang, S.S.; Wang, G.L.; Wu, T.L.; Lv, Y.L.; Wu, Q.M. A Pregnant Mouse Model for the Vertical Transmission of Brucella melitensis. Vet. J. 2014, 200, 116–121. https://doi.org/10.1016/j.tvjl.2013.12.021. 41. Byndloss, M.X.; Tsai, A.Y.; Walker, G.T.; Miller, C.N.; Young, B.M.; English, B.C.; Seyffert, N.; Kerrinnes, T.; de Jong, M.F.; Atluri, V.L.; et al. Brucella abortus Infection of Placental Trophoblasts Triggers Endoplasmic Reticulum Stress-Mediated Cell Death and Fetal Loss via Type IV Secretion System-Dependent Activation of CHOP. mBio 2019, 10, e01538-19. https://doi.org/10.1128/mBio.01538-19. 62. Bosseray, N. Kinetics of Placental Colonization of Mice Inoculated Intravenously with Brucella abortus at Day 15 of Pregnancy. Br. J. Exp. Pathol. 1983, 64, 612–616. 63. Bosseray, N. Mother to Young Transmission of Brucella abortus Infection in Mouse Model. Ann. Rech. Vet. 1982, 13, 341–349. 64. Bosseray, N. Vaccine and Serum-Mediated Protection against Brucella Infection of Mouse Placenta. Br. J. Exp. Pathol. 1983, 64, 617–625. 65. Bosseray, N.; Plommet, M. Serum- and Cell-Mediated Immune Protection of Mouse Placenta and Fetus against a Brucella abortus Challenge: Expression of Barrier Effect of Placenta. Placenta 1988, 9, 65–79. https://doi.org/10.1016/0143-4004(88)90074-4. 66. Watanabe, K.; Iwai, N.; Tachibana, M.; Furuoka, H.; Suzuki, H.; Watarai, M. Regulated upon Activation Normal T-Cell Expressed and Secreted (RANTES) Contributes to Abortion Caused by Brucella abortus Infection in Pregnant Mice. J. Vet. Med. Sci. 2008, 70, 681–686. https://doi.org/10.1292/jvms.70.681. 67. Watanabe, K.; Tachibana, M.; Tanaka, S.; Furuoka, H.; Horiuchi, M.; Suzuki, H.; Watarai, M. Heat Shock Cognate Protein 70 Contributes to Brucella Invasion into Trophoblast Giant Cells That Cause Infectious Abortion. BMC Microbiol. 2008, 8, 212. https://doi.org/10.1186/1471-2180-8-212. 68. Hashino, M.; Kim, S.; Tachibana, M.; Shimizu, T.; Watarai, M. Vertical Transmission of Brucella abortus Causes Sterility in Pregnant Mice. J. Vet. Med. Sci. 2012, 74, 1075–1077. https://doi.org/10.1292/jvms.11-0566. 69. Barbier, T.; Machelart, A.; Zúñiga-Ripa, A.; Plovier, H.; Hougardy, C.; Lobet, E.; Willemart, K.; Muraille, E.; De Bolle, X.; Van Schaftingen, E.; et al. Erythritol Availability in Bovine, Murine and Human Models Highlights a Potential Role for the Host Aldose Reductase during Brucella Infection. Front. Microbiol. 2017, 8, 1088. https://doi.org/10.3389/fmicb.2017.01088. 71. Keestra-Gounder, A.M.; Byndloss, M.X.; Seyffert, N.; Young, B.M.; Chávez-Arroyo, A.; Tsai, A.Y.; Cevallos, S.A.; Winter, M.G.; Pham, O.H.; Tiffany, C.R.; et al. NOD1 and NOD2 Signalling Links ER Stress with Inflammation. Nature 2016, 532, 394–397. https://doi.org/10.1038/nature17631. 72. Tsai, A.Y.; Byndloss, M.X.; Seyffert, N.; Winter, M.G.; Young, B.M.; Tsolis, R.M. Tumor Necrosis Factor Alpha Contributes to Inflammatory Pathology in the Placenta during Brucella abortus Infection. Infect. Immun. 2022, 90, e0001322. https://doi.org/10.1128/iai.00013-22. 73. Poveda-Urkixo, I.; Ramírez, G.A.; Grilló, M.-J. Kinetics of Placental Infection by Different Smooth Brucella Strains in Mice. Pathogens 2022, 11, 279. https://doi.org/10.3390/pathogens11030279. 74. Zabalza-Baranguá, A.; Poveda-Urkixo, I.; Mena-Bueno, S.; Ramírez, G.A.; De Bolle, X.; Grilló, M.J. Vaccine Properties of Brucella melitensis 16MΔwzm and Reactivation of Placental Infection in Pregnant Sheep. Vaccine 2023, 41, 1554–1566. https://doi.org/10.1016/j.vaccine.2023.01.017. 75. Mena-Bueno, S.; Poveda-Urkixo, I.; Irazoki, O.; Palacios, L.; Cava, F.; Zabalza-Baranguá, A.; Grilló, M.J. Brucella melitensis Wzm/Wzt System: Changes in the Bacterial Envelope Lead to Improved Rev1Δwzm Vaccine Properties. Front. Microbiol. 2022, 13, 908495. https://doi.org/10.3389/fmicb.2022.908495. 76. Braz, H.M.B.; Silva, M.F.; de Carvalho, T.P.; da Silva, L.A.; Soares, J.B.; Costa, F.B.; Sossai, B.G.; Paixão, T.A. da; Santos, R.L. Pathogenesis of Brucella ovis in Pregnant Mice and Protection Induced by the Candidate Vaccine Strain B. ovis ΔabcBA. Vaccine 2022, 40, 4617–4624. https://doi.org/10.1016/j.vaccine.2022.06.044. 82. Adetunji, S.A.; Faustman, D.L.; Adams, L.G.; Garcia-Gonzalez, D.G.; Hensel, M.E.; Khalaf, O.H.; Arenas-Gamboa, A.M. Brucella abortus and Pregnancy in Mice: Impact of Chronic Infection on Fertility and the Role of Regulatory T Cells in Tissue Colonization. Infect. Immun. 2020, 88, e00257-20. https://doi.org/10.1128/IAI.00257-20. 83. Ren, J.; Hou, H.; Zhao, W.; Wang, J.; Peng, Q. Administration of Exogenous Progesterone Protects Against Brucella abortus Infection–Induced Inflammation in Pregnant Mice. J. Infect. Dis. 2021, 224, 532–543. https://doi.org/10.1093/infdis/jiaa722.