COMPARATIVE EFFICACY AND SAFETY OF INTRAMUSCULAR MIDAZOLAM VERSUS INTRAVENOUS LORAZEPAM IN PREHOSPITAL MANAGEMENT OF STATUS EPILEPTICUS: EVIDENCE FROM RAMPART TRIAL

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Authors: P. Priyadharshini*1, S. Lakshmi1, V. Anushree1, M. Praveenkumar2, C. Jothimanivannan3
Cited by: 0

Abstract

Background: Status Epilepticus (SE) is a life-threatening neurological emergency that requires immediate treatment. Intravenous (IV) lorazepam is a standard first-line therapy, but IV access is often delayed in Prehospital settings. Intramuscular (IM) Midazolam offers a potential alternative due to its ease of administration. Objective: To evaluate and compare the effectiveness of IM midazolam and IV lorazepam in terminating seizures in patients with status epilepticus in a Prehospital setting.

Fields of Study & Subjects

Epilepsy research and treatment Anesthesia and Sedative Agents Electroconvulsive Therapy Studies

Publication details

Journal / source
World Journal of Pharmaceutical Research
Publication date
16 January 2026
Language
EN