ENGIN: Edge-Native Genomic Inspection Node

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Authors: Aravind Suresh
Cited by: 0

Abstract

ENGIN is a real-time genomic filtration protocol designed to perform Deep Packet Inspection (DPI) on FASTQ data streams. It functions as a biological firewall, utilizing a Negative Selection algorithm to minimize storage overhead in clinical sequencing workflows. Methodology: This repository contains the reference implementation (v1.0-Beta) utilizing Whole-Read Exact Matching. Unlike probabilistic filters (Bloom Filters) or sliding-window K-mers, this implementation enforces high-stringency filtration, discarding reads only if they match the host reference database with 100% identity. This approach ensures zero false-positive deletion of foreign/pathogenic data while significantly reducing background noise.

Fields of Study & Subjects

Genomics and Phylogenetic Studies Network Packet Processing and Optimization Algorithms and Data Compression

Publication details

Journal / source
Zenodo (CERN European Organization for Nuclear Research)
Publication date
15 January 2026