Review on Green Synthesis of 3-4dihydropyrimidinone Using NaDES

The present project focuses on the green synthesis of 3,4-dihydropyrimidinones (DHPMs) using Natural Deep Eutectic Solvents (NaDES) as an eco-friendly reaction medium. DHPMs are important heterocyclic compounds possessing various pharmacological activities such as antibacterial, anti-inflammatory, and antihypertensive properties. The synthesis was carried out through the Biginelli reaction involving an aldehyde, β-ketoester, and urea in the presence of NaDES. The use of NaDES not only replaces toxic organic solvents but also improves reaction efficiency, giving high yields in a shorter time. This method follows the principles of green chemistry and provides a sustainable and efficient approach for the synthesis of biologically active heterocyclic compounds.