To Formulate and Evaluate of Rivaroxaban Immediate Release Tablets Using Super Disintegrants and Surfactant

The present study aimed to formulate and evaluate immediate release tablets of rivaroxaban using superdisintegrants and a surfactant to enhance dissolution and oral bioavailability. Rivaroxaban, a poorly water-soluble anticoagulant, exhibits dissolution- limited absorption, necessitating formulation strategies to improve its release profile. Immediate release tablets were prepared by direct compression employing different concentrations of superdisintegrants such as croscarmellose sodium, sodium starch glycolate, and crospovidone, along with a suitable surfactant to improve wettability and drug dispersion. The prepared formulations were evaluated for pre-compression parameters including angle of repose, bulk density, tapped density, Carr’s index, and Hausner’s ratio, which indicated satisfactory flow properties. Post-compression evaluation involved assessment of tablet hardness, thickness, friability, weight variation, drug content uniformity, disintegration time, and in vitro dissolution studies. The optimized formulation demonstrated acceptable physicochemical properties, rapid disintegration, and significantly enhanced drug release compared to formulations without surfactant. In vitro dissolution results showed compliance with pharmacopeial requirements for immediate release dosage forms. The study concludes that the combined use of superdisintegrants and surfactant is an effective approach for developing immediate release rivaroxaban tablets with improved dissolution characteristics, potentially leading to better therapeutic performance.