A Review on SNESNS: An Effective Method for Delivering Poorly Soluble Drugs

Self-nanoemulsifying self-nanosuspension (SNESNS) represents a new type of oral drug delivery system that can be used to overcome the prob.lem of poor water solubility in the case of a wide range of pharmaceutical agents. Under the umbrella of the benefits of selfnanoemulsifying drug delivery system (SNEDDS) and nanosuspensions, SNESNS seeks to enhance the dissolution rate, bioavail.ability, and solubility. This twin action permits the drugs to circumvent the liver and is transported more rapidly to the systemic circulation that increases its bioavailability and effect. The most important one is the abil.ity to load drugs that are larger in quantity than traditional SNEDDS that are especially useful when dealing with drugs with a high potency or low solubility. Recent literature has concentrated on the SNESNS solidification to achieve stability of the formulation and convenience in use to patients through the use of carriers such as mesoporous silica or through the use of the spray drying method. In addition, targeted and multiple drug delivery (3D printing and surface modification) is being explored to attain personalized approaches of drug delivery. The progression of formulation tools (including phase diagram mapping and statistical optimization) is related to the presence of sufficient drug loading and release characteristics. On the whole, SNESNS is an all-encompassing approach and innovative concept of the design of the stable and effective oral formulations with effects on a variety of treatment fields.