Phytochemical Investigation and Herbal Cream Development from Acalypha Fruticosa Forssk Ethanolic Extract

This study aims to investigate the phytochemical constituents of Acalypha fruticosa Forssk ethanolic extract and to develop and evaluate a herbal cream intended for topical application in skin-related disorders. Acalypha fruticosa, a traditionally used medicinal plant, is known for its anti-inflammatory, antimicrobial, and wound-healing properties, making it a promising candidate for herbal dermatological formulations. The aerial parts of the plant were collected, authenticated, and subjected to Soxhlet extraction using 70% ethanol. Preliminary phytochemical screening revealed the presence of bioactive constituents such as alkaloids, flavonoids, tannins, phenolic compounds, saponins, steroids, and glycosides. Alkaloid constituents were further confirmed using thin layer chromatography (TLC). Based on the phytochemical findings, a water-in-oil (W/O) type herbal cream was formulated incorporating the ethanolic extract along with suitable excipients. The formulated creams were evaluated for physicochemical parameters including appearance, pH, viscosity, spreadability, homogeneity, phase separation, and stability. The optimized formulation demonstrated acceptable pH suitable for skin application, good spreadability, appropriate viscosity, and stability without any signs of phase separation. The study highlights the potential of Acalypha fruticosa as a valuable herbal ingredient in topical formulations and supports its traditional use in the management of skin ailments. Further biological and dermatological studies are warranted to establish its therapeutic efficacy and clinical applicability.