Formulation and Evaluation of Mouth Dissolving Tablet of Quetiapine Fumarate

The oral route administration is regarded the most favorable over other routes due to its simplicity, convenience of usage, patient compliance, cost – effectiveness, and painlessness. It is also the safest way of administration. Recent years have seen difficulties with standard dosage forms including patients who are unable to take oral medicament due to dysphasia, unconsciousness, behavioral disorders or CNS abnormalities. So, the first modern alternative to conventional dosage form is to initiate a rapid and swift breakdown in the oral cavity to solve these issues. Mouth dissolving tablets seems to be demanding, promising & one of the most extensively used dosage form over the conventional ones. The development of MDTs aims to provide products with adequate hardness, integrity, taste masking property, pleasant mouth feel, and quick disintegration without needs of water within short time period. Quetiapine fumarate is atypical antipsychotic drug, used in the treatment of schizophrenia and bipolar disorders. Conventional dosage form of Quetiapine fumarate available in the market is not suitable where quick onset of action is required. However, drug is extensively metabolized by the liver, therefore bioavailability is also less. As the antipsychotic patients need to be calm as quickly as possible, the patients are benefited by proposed drug delivery by reaching the drug to the systemic circulation within short time by oral delivery.