Synthesis and Biological Evaluation of Some Thiadiazole Derivatives as Antitubercular Agents

The increasing prevalence of multidrug-resistant tuberculosis has created an urgent need for new and effective antitubercular agents. Thiadiazole derivatives are known for their diverse pharmacological properties, particularly antimicrobial activity, making them attractive candidates for tuberculosis drug discovery. In the present study, a series of novel thiadiazole derivatives were synthesized and evaluated for their antitubercular potential. The compounds were prepared using a multistep synthetic pathway and were characterized by FT-IR, ¹H-NMR, and mass spectrometry to confirm their chemical structures. The synthesized molecules were screened for in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv strain using standard microbiological techniques. Several derivatives exhibited notable inhibitory activity, indicating promising antitubercular potential. Structure–activity relationship studies suggested that the nature and position of substituents on the thiadiazole ring significantly influenced biological activity. These findings highlight thiadiazole derivatives as valuable lead compounds for the development of new antitubercular drugs.