Data from Rossen et al. 2026 medRxiv, "Per-allele disease and complex trait effect sizes are predominantly African MAF-dependent in European populations"

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Authors: Jordan Rossen
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Abstract

Data from Rossen et al. 2026 medRxiv, "Per-allele disease and complex trait effect sizes are predominantly African MAF-dependent in European populations". https://www.medrxiv.org/content/10.64898/2025.12.31.25343290v2 maf_censored.tsv.gz contains 3 allele frequency measurements. MAF_afr70346 contains allele frequencies for 70,346 African-ancestry individuals from All of Us v8 (assigned using continental ancestry groups defined by All of Us). MAF_eur70346 contains allele frequencies for 70,346 European-ancestry individuals from All of Us v8 (assigned using continental ancestry groups defined by All of Us). MAF_afr_unadmixed contains unadmixed African allele frequencies, estimated by restricting to African individuals with two African haplotypes locally (this computation was restricted to 46,672 African ancestry individuals who were present in All of Us v7; see methods section of manuscript for further details). Note the following: We restricted to variants with either African MAF > 0.001 or European MAF > 0.001, and missingness < 0.05 in both European and African ancestries, according to the All of Us Variant Annotation Table. Allele frequency calls corresponding to MAC

Fields of Study & Subjects

Genetic Associations and Epidemiology Forensic and Genetic Research Race Genetics and Society

Publication details

Journal / source
Zenodo (CERN European Organization for Nuclear Research)
Publication date
18 January 2026
Document type
Dataset