Which antidepressants are most effective for preventing migraine headaches?

Zenodo (CERN European Organization for Nuclear Research) 2026 Open access

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Authors: Tripdatabase
DOI: 10.5281/zenodo.18304745
Cited by: 0

Abstract

Antidepressants, primarily amitriptyline, may be effective for migraine prevention, though their use can be limited by side effects. SSRIs and SNRIs show less consistent efficacy in existing studies.

Fields of Study & Subjects

Migraine and Headache Studies Temporomandibular Joint Disorders Intracranial Aneurysms: Treatment and Complications

Publication details

Journal / source
Zenodo (CERN European Organization for Nuclear Research)
Publication date
19 January 2026