New Daily Persistent Headache as a Rapid Resonant Lock-In State A Sympathetic Harmonic Resonance Framework (SHRF) Interpretation

Abstract New Daily Persistent Headache (NDPH) is a primary headache disorder defined by a sudden, clearly remembered onset followed by continuous, unremitting headache persisting for at least three months. Despite well-defined diagnostic criteria, NDPH remains mechanistically unexplained and therapeutically refractory in many patients. We propose that NDPH is best understood not as a slowly progressive sensitization disorder, but as a rapid phase transition into a stable high-gain state within coupled nociceptive, autonomic, and immune-modulated neural networks. Within the Sympathetic Harmonic Resonance Framework (SHRF), NDPH represents a resonance lock-in phenomenon triggered by acute perturbations such as infection, stress, or peripheral afferent overload. This framing explains the abrupt onset, persistence, and heterogeneity of treatment response, and yields falsifiable predictions for biomarker stratification, dynamical signatures, and therapeutic response geometry. The model is intentionally minimal and designed for incremental empirical testing.