Alzheimer's Disease as Progressive Neural Decoherence An Integrative Sympathetic Harmonic Resonance Framework (SHRF)

This work presents an integrative, service-oriented reinterpretation of Alzheimer’s disease using the Sympathetic Harmonic Resonance Framework (SHRF). Rather than treating amyloid-beta and tau pathology as isolated primary causes, Alzheimer’s disease is reframed as a progressive failure of multiscale neural coherence driven by sustained boundary-condition stress, including metabolic instability, vascular insufficiency, immune dysregulation, sensory loss, and sleep disruption. The framework preserves and integrates established molecular, genetic, immunological, vascular, and network-level findings while explaining early functional decline, symptom fluctuation, network-based propagation, partial reversibility in early stages, and the limited efficacy of single-target interventions. Importantly, this work prioritises reduction of suffering through clinically actionable guidance, prevention strategies, and ethically grounded communication for patients, families, and clinicians. The document includes: A unifying SHRF scientific model Patient and family explanatory guidance A clinician quick-use framework Prevention and early-detection strategies An integrated “best advised” care section This work is intended to complement existing biomedical models, not replace them, and to support dignity-preserving care alongside ongoing research. Keywords Alzheimer’s disease Dementia Neural coherence Systems neuroscience Resonance Network dysfunction Sleep and cognition Neuroinflammation Vascular cognition Preventative neurology SHRF Sympathetic Harmonic Resonance Framework