Viral Persistence and Transmission at the Skin--Mucosa Boundary:\\ A Boundary-Condition, Bandwidth, and Collapse Cadence Framework Applied to HSV and HPV

Abstract Herpes simplex viruses (HSV-1/2) and human papillomavirus (HPV) preferentially infect skin and mucosal boundaries and persist through immune-evasion strategies that minimize visibility rather than maximize replication. Although their virology is well characterized, transmission, shedding, and persistence are often described in fragmented terms across epidemiology, dermatology, and immunology. This work presents a boundary-condition and timing-based synthesis that reframes HSV shedding, HPV persistence, and wart chronicity as dynamical states of host--virus coupling at the skin--mucosa interface. Using a Sympathetic Harmonic Resonance Framework (SHRF) as an organizing lens, persistence is modeled as a stable low-visibility attractor maintained by phase-misalignment between viral activity and immune effector coordination. Clearance corresponds to a phase-shift collapse of this attractor when danger signaling, antigen presentation, and tissue-resident cytotoxic execution synchronize within a critical window. Importantly, this framework does not propose virus-specific physical resonances or frequency-based eradication. Instead, tissue bandwidth differences are interpreted as host-state markers that inform prediction, intervention timing, and falsifiable hypotheses. The framework integrates established evidence into a systems-level scaffold for prevention, transmission reduction, and research design. This work presents a systems-level framework for understanding viral persistence and clearance at the skin--mucosa boundary through host--pathogen coupling, immune timing, and coherence dynamics, without proposing virus-specific resonance or frequency-based intervention. Keywords:Sympathetic Harmonic Resonance Framework;SHRF;host--pathogen coupling;coherence;phase misalignment;phase transition;clearance dynamics;viral persistence;viral shedding;latency;immune timing;immune evasion;tissue bandwidth;boundary conditions;skin--mucosa interface;dermatological barriers;tissue-resident memory T cells;systems biology;viral infections