Establishing Robust In Vitro and In Vivo Models of Mesothelioma for Enhanced Translational Research (Conference Abstract)

Malignant pleural mesothelioma (MPM) is a fatal cancer, where one of the primary risk factor remains asbestos exposure. Developing robust, safe, and efficient therapeutic targets, along with models that accurately recapitulate the disease is critical for improving MPM therapeutic strategies. This study aims to modulate nucleolin (NCL), a protein ubiquitously expressed in the cell nucleus and specifically present in the cytoplasmic membrane of some cancer malignancies, and develop a robust in vivo orthotopic model in order to explore additional mechanistic insights on tumor drug targeting as was successfuly performed by our group previously.