Personalized Neoadjuvant Intra-Arterial Chemotherapy for Gastric Cancer

Acquaintance The problem of treating locally advanced gastric cancer, as well as stage IV gastric cancer, is currently far from being solved [7, 8, 10, 13-15]. Patients with stage IV disease and stage IV gastric cancer often do not receive sufficient specialized medical care and are transferred for further treatment and observation to palliative care and symptomatic treatment groups [15, 19, 22]. The Republican Oncology Center named after Professor G.V. Bondar in Donetsk, which provides medical care in a region comparable in number of people to the state of Norway, has accumulated sufficient experience in treating patients with malignant gastric lesions [2]. In the 1960s, Academician G.V. Bondar proposed and implemented a method of esophagojejunostomy after gastrectomy , and this method remains one of the most reliable, as anastomotic suture failure is the most severe complication after gastrointestinal surgery (the anastomotic area is additionally covered by an afferent loop of the small intestine) [6, 11]. We practically never encounter the problem of esophagojejunostomy suture failure in routine practice. There are unresolved issues regarding the treatment tactics for patients with tumor stenosis of the gastric outlet, anemia, intoxication, and chemo-refractory gastric cancer. The authors will attempt in this publication to propose a solution to some of these problems [7, 8, 10, 14, 19].