Why is plasma clozapine approximately 20-30% lower in smokers compared to non-smokers?

Zenodo (CERN European Organization for Nuclear Research) 2026 Open access

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Authors: Tripdatabase
DOI: 10.5281/zenodo.18392592
Cited by: 0

Abstract

Plasma clozapine levels are approximately 20-30% lower in smokers compared to non-smokers due to the induction of hepatic enzymes like CYP1A2 by tobacco smoke, leading to increased drug metabolism.

Fields of Study & Subjects

Pharmacogenetics and Drug Metabolism Smoking Behavior and Cessation Drug-Induced Hepatotoxicity and Protection

Publication details

Journal / source
Zenodo (CERN European Organization for Nuclear Research)
Publication date
27 January 2026