Anastomotic Leak and Stricture in Colorectal Surgery: A Systematic Review and Meta-Analysis

Zenodo (CERN European Organization for Nuclear Research) 2026 Open access

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Authors: Anna Lemańska, Kornella Zieleń, Sandra Moska, Dagmara Kanar, Izabela Majchrzak, Joanna Cygan, Martyna Lenartowicz, Antonina Woźnicka, Julia Klincewicz
DOI: 10.5281/zenodo.18397291
Cited by: 0

Abstract

Abstract Background: Anastomotic leak (AL) and stricture (AS) are major complications of colorectal surgery. This systematic review synthesizes evidence on risk factors, prevention strategies, and management. Methods: Comprehensive search of PubMed, Cochrane, Scopus, Embase, Web of Science (inception–July 2024). Meta-analysis using random-effects models with GRADE assessment. Study quality evaluated using MINORS and RoB 2 tools. Results: 66 studies included (11,560 patients). Risk factors for AL: male sex (OR 1.53, 95% CI 1.23–1.91), low rectal location 30 kg/m². Intraoperative perfusion assessment significantly reduced AL rates (7.4% vs 12.4%, p

Fields of Study & Subjects

Colorectal Cancer Surgical Treatments Enhanced Recovery After Surgery Stoma care and complications

Publication details

Journal / source
Zenodo (CERN European Organization for Nuclear Research)
Publication date
28 January 2026
Language
EN