A Review on Therapeutic Role of Magnifera Indica Leaves In Diabetes Management

Diabetes mellitus is a long-term metabolic disorder mainly caused by either low insulin production or the body not responding properly to insulin. This leads to increased blood glucose levels due to problems such as reduced glucose uptake by cells, increased glucose production in the liver, and damage to pancreatic β-cells. Mango leaves (Mangifera indica) have been used traditionally to support diabetes management, and many studies now explain their scientific benefits. Mango leaves contain active compounds like magniferin quercetin, catechins, and phenolic acids, which help improve diabetic conditions through multiple mechanisms. These compounds can enhance insulin secretion, increase insulin sensitivity, reduce intestinal glucose absorption, and control enzymes involved in carbohydrate breakdown. Mango leaves also reduce oxidative stress and inflammation, which are major factors causing β-cell damage in diabetes. Animal and preliminary human studies show improvements in fasting blood sugar, lipid profile, and antioxidant levels. Although the results are promising, more clinical trials are still needed. Overall, mango leaves show strong potential as a natural supportive therapy for diabetes management.